Cells are complex environments and this might have a large impact on how linear aggregates (e.g. amyloid fibrils that play an important role in diseases such as Alzheimer’s and Parkinson’s) form. In our new study, published in the Biophysical Journal, we investigate how the rheology of liquid droplets can affect the partitioning of irreversibly aggregating proteins.
This project was a great collaboration with Thomas Michaels (University of Zurich) and Christoph Weber (University of Augsburg). Stay tuned, we will soon publish more on this topic!